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HomeHealthStudy finds crucial link between bowel disease (IBD) and antibiotic use

Study finds crucial link between bowel disease (IBD) and antibiotic use

A groundbreaking study has revealed critical insights into how the use of antibiotics increases the risk of inflammatory bowel disease (IBD). Published in Science Advances, the research demonstrates that antibiotics disrupt the protective mucus layer in the intestine, a finding that could transform our understanding of the relationship between antibiotics and the development of IBD, according to the researchers.

IBD, which encompasses Crohn’s disease and ulcerative colitis, affects about 1% of the global population and leads to severe symptoms. While research is ongoing, the precise causes of IBD are still not fully understood. However, previous studies have suggested a correlation between antibiotic use and a heightened risk of developing IBD.

In this study, scientists employed cutting-edge methods such as RNA sequencing, machine learning, and measurements of mucus secretion to evaluate the effects of antibiotics in mouse models.

Secretion impaired

The results indicated that antibiotics impair the secretion of protective mucus, resulting in bacterial infiltration, systemic replication of bacterial antigens, and the formation of ulcers.

“We have discovered that antibiotic use damages the protective mucus layer that separates the immune system in the gut from the microbiome,” stated Dr. Shai Bel from the Azrieli Faculty of Medicine at Bar-Ilan University in a press release.

His team’s study reveals that antibiotics, whether administered orally or via injection, disrupt this vital mucus layer, facilitating bacterial penetration and increasing the risk of gut inflammation.

One of the most striking findings of the study is that antibiotics’ impact on the mucus barrier is not due to alterations in the microbiome but rather affects the cells in the intestinal wall responsible for mucus production.

“This finding shatters the paradigm that antibiotics harm only bacteria and not our own cells,” Dr. Bel said.

The research team now plans to explore potential treatments that could mitigate the adverse effects of antibiotics on mucus secretion.

WFL
WFLhttp://wholefoodliving.life
Whole Food Living reviews and selects material from a wide variety of international sources. Our primary focus covers food, health and environment. We publish fact checked official announcements made as the result of formal studies conducted by Universities, respected health care organisations, journals, and scientists around the globe.
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